The launch editor was Gareth Herincx, who vacated the hotseat during the construction of issue 3 at which point Tim Ponting took over. Reviewers for the launch issue were: Jonathan Davies, Sean Kelly, Duncan MacDonald, David McCandless, Marcus 'Binky' Berkmann, and Matt Bielby (all former writers for Your Sinclair). Other journalists of note who passed through Zero's hallowed chambers included David 'Whistlin' Rick' Wilson, 'Lord' Paul Lakin, Amaya Lopez, Jackie Sutton, Rich Pelley and Jane Goldman.

Issue 1 contained a coverdisk containing two free games for the Amiga and Atari ST. A regular coverdisk was later introduced which included full games and playable demos. Zero caused controversy when issue 31 included a playable demo of Cover Girl Poker on the cover disk. This resulted in the magazine being banned from the leading newsagents. By issue 33 the magazine was re-designed without the spine and had taken on a more youth orientated look.

Like many similar magazines, it contained sections of news, game reviews, previews, tips, help guides, columnists, reader's letters, and cover-mounted disks of game demos. Some memorable features include "highest joystick" where readers would send in a picture of their gaming apparatus of choice at a high location, such as Ben Nevis or the cockpit of a jet (next to the altimeter), a feature where readers could send in a picture of themselves with a celebrity (One such picture had a topless Richard Branson with two young brothers), and "Smack In The Marf", in which readers could send in (obviously faked) pictures of themselves with their injuries.

The magazine was notable for the considerable off-beat adolescent humour and wordplay used throughout the magazine — a continuation of the style first seen in Your Sinclair. Zero is the precursor to the humorous style of writing used in magazines such as PC Zone, and in fact many of the original writers who contributed to Zero went on to submit work for PC Zone.