INFO=64 began as a newsletter published by its founder, Benn Dunnington, operating out of a spare bedroom in his home. After a few issues, the entrepreneurial spirit struck and he decided to expand it into a full-fledged magazine. The first few issues of the magazine were published by Dunnington operating as a sole proprietorship in the state of Washington. After a few issues, he moved the company to Iowa, eventually incorporating as Info Publications, Inc.. This, in turn, became a limited partnership, (Info Publications Ltd), which published the magazine until its demise. NFO=64 was produced using personal computers. An editorial statement in each issue explained that the magazine was produced using only "lay equipment", such as home computers and 35mm cameras, that were inexpensively available to the general public. Early issues were typeset using a Commodore 64 and a dot-matrix printer, giving the magazine a distinctive hand-crafted appearance. The magazine soon switched to a more professional appearance using laser printers and Newsroom and GEOS software for the 8-bit Commodores, before changing its editorial focus and publishing platform to the Amiga, and changing its name to .info, which was coincidentally the file extension of Amiga icon files.

Over the course of its run, .info absorbed three pioneering Commodore magazines that ceased publication during the "great extinction" that struck computer magazines in the late 1980s. These were Jim Oldfield and James Strassma's Midnite Software Gazette (which had previously absorbed 'The Paper', one of the oldest independent publications supporting Commodore computers), Mitch Lopes' RoboCity News (the one-time official publication of FAUG, the First Amiga Users' Group, before it was spun off), and Chris Zamara and Nick Sullivan's Transactor (the official publication of TPUG, the Toronto PET Users' Group). Unfortunately, when .info ceased publication, the receivers stood in the way of allowing .info's publisher to find another magazine to fulfill its subscriptions.